2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Dopamine Receptor
  5. D1 Receptor Isoform
  6. D1 Receptor Inhibitor

D1 Receptor Inhibitor

D1 Receptor Inhibitors (5):

Cat. No. Product Name Effect Purity
  • HY-175001
    D1/D5 Receptor agonist-1
    		Inhibitor
    D1/D5 Receptor agonist-1 is a highly brain-penetrant and orally active D1/D5 receptor agonist. D1/D5 Receptor agonist-1 maintains considerable efficacy in the cAMP pathway and in β-arrestin recruitment, with EC50s of 3.7 nM (D1R cAMP), 91 nM (D1R β-arrestin), 129 nM (D1R internalization) and a Ki of 111 nM (D1R binding affinity). D1/D5 Receptor agonist-1 inhibits β-arrestin signaling in a rat with L-DOPA (HY-N0304) induced dyskinesias. D1/D5 Receptor agonist-1 can be used for the study of Parkinson’s disease.
  • HY-17390A
    Loxapine succinate
    		Inhibitor 98.84%
    Loxapine succinate is an orally active dopamine inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent. Loxapine can also suppresses bacterial efflux pump activity and inhibit intracellular multiple-antibiotic-resistant Salmonella enterica serovar Typhimurium in macrophages.
  • HY-17390
    Loxapine
    		Inhibitor 99.93%
    Loxapine is an orally active dopamine inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent.
  • HY-N5140
    Bacopaside X
    		Inhibitor ≥99.0%
    Bacopaside X is found in Bacopa monnieri, and shows a binding affinity toward the D1 receptor.
  • HY-17390B
    Loxapine hydrochloride
    		Inhibitor
    Loxapine hydrochloride is an orally active dopamine inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent.